1. Introduction

If you want collagen, beauty, skin regeneration, anti-aging, your answer is very simple: L-Lysine and essential amino acids (Thot Aminos) – the best and only way… Then you can skip the science.

In order to produce collagen, you need a lot of L-Lysine and vitamin C
Bralgei Shackry aka Gabriel Pesa

L-Lysine and Thot Aminos is the key to collagen, beauty, skin regeneration, anti-aging. — L-Lysine the key to collagen and healthy body

Is that all? Yes. Your body can produce collagen if you have these 2 ingredients.

We give you the highest grade and the highest concentration of L-Lysine on the market.

You take care of the vitamin C

…now let’s go into details and science

Of all the 9 essential amino acids, L-Lysine is a special one when it comes to human body structure, beauty and cosmetics (skin, tendons, blood vessels, cartilages, bones and connective tissue – which anchors cells to each other).

Yes, I’m talking about L-Lysine because it is known especially for collagen synthesis, skin and for stabilizing the structural matrix. Collagen is the most abundant protein in our body[1]. It represents between 25-35% of all proteins and 75% of skin. There is an entire beauty industry . However, few people know the real science behind the production, regeneration and long-time maintenance of the matrix.

There are 28 known types of collagen the most abundant being type I – 90% (skin, tendon, vasculature, organs, bone), type II (cartilage), type III (reticular fibers) and type IV (basement membrane).

The story around collagen is pretty long and complicated, but here you have the opportunity to get the most important conclusions after years of studying and learning about such an important protein. Two of the key essential elements are L-Lysine and Vitamin C. One is an essential amino acid and the other is an essential vitamin. Neither one can be produced by the body. Skin and anti-aging is depending on them.

Don’t you find it a little odd that the synthesis of the most abundant protein in the body depends on two elements that the body cannot produce? Have you ever asked yourself why? I might be wrong, but… depending on an outside nutrient might be one of the Universe’s elegant ways to show to the arrogant human being that he is still part of something bigger than himself.

Coming back to collagen, there are a lot of hydrolyzed forms that are being sold in the entire world. The question is: are supplements really effective? There is a huge debate around this topic: some studies say they work, some say they are not that effective. If you want to see more on this matter, I highly encourage you to read some articles:

Cosmetics industries understood the importance of L-Lysine in skin health and care. Doctors around the world shared their view on L-Lysine and its recognized skincare benefits[2]. However, L-Lysine is not the only factor in this equation. One must not rely on one supplement for its rejuvenating properties. Vitamin C is too a key element, but a proper cellular hydration and a healthy lifestyle is a must. Then we can talk supplements.

L-Lysine is the most effective essential amino acid in skin rejuvenation and it significantly improves our appearance. But L-Lysine does much more than that when it comes to overall health. Together we will discover the details about L-Lysine and its functions, benefits and uses.

Take your time and enjoy reading our article!

2. L-Lysine and Essential Amino Acids in Health, Body Structure and Beauty

L-Lysine is the most important beauty-oriented amino acid of all the 9 essential amino acids (EAAs). This amino acid has many essential roles in various body functions. All of these roles and pathways will be presented in detail. But first, let’s recap:

2.1. What are Essential Amino Acids?

Amino acids are the building blocks of life[3] – they are indispensable to life – the ones the body uses to build up proteins, hormones, neurotransmitters and all that is necessary.

There are 20 amino acids in nature, of which 9 are essential amino acids (they must be supplemented from food, as the human body cannot synthesize them): L-Leucine, L-valine, L-isoleucine, L-tryptophan, L-phenylalanine, L-methionine, L-lysine, L-threonine, L-histidine

Amino acids and enzymes are the key supplements that underlie the optimal functioning of protein metabolism. This is the indispensable team for the human body performance. The reality is that we are all deficient in amino acids. For the curious people, there are test panels for amino acid deficiencies[3].

Amino acids are used for protein synthesis. Proteins are really the molecules that keep our body alive and running. Life would not exist without proteins. And life thrives when we have the right proteins. Most people believe that it is proteins that we need to take out from our diet. I love to break it to you: it’s not proteins, it’s an amino-acids that we need.

The body cannot absorb proteins. They are digested by enzymes and broken down into amino acids. They are absorbed and used to build the appropriate proteins for the human body. I repeat. It’s the amino acids that we need.

2.2 Why ESSENTIAL (INDISPENSABILE) Amino Acids?

As I’ve already mentioned above, essential amino acids are those 9 amino acids that the human body, in the evolutionary process, has lost the genetic ability to synthetize. Therefore, they need to be supplemented from an outside source.

These are the 9 essential amino acids – their roles in the human body:

L-Leucine – stimulates muscle protein synthesis, being directly involved in the functions of anabolism or body growth and development[5].
L-Lysine – is involved in the most important regulatory processes like gene expression, cellular metabolism and protein stability. Practically, L-Lysine is the key to epigenetics[6] and is essential in longevity and regeneration.
L-Isoleucine – is an important regulator of blood sugar, muscle repair and energy regulation[7].
L-Valine – is both an EAA and a BCAA. It is needed for muscle, tissue repair and maintaining an optimal level of nitrogen in the body. Along with leucine and isoleucine, it helps protect muscle tissue[8].
L-Threonine – is important for the production of antibodies, for the immune system and can be converted to glycine and serine. It also contributes to the synthesis of collagen, elastin and tooth enamel and helps in liver metabolism[9].
L-Phenylalanine – stimulates the synthesis and release of neurotransmitters and hormones such as dopamine and norepinephrine, substances necessary for the optimal activity of the Central Nervous System and the Peripheral Nervous System. They are basically the two neurotransmitters that make us “feel good” and get over an intense pain or an unpleasant event more easily[10].
L-Methionine – provides the body with sulfur – sulfur is very important in the synthesis of glutathione – the most powerful antioxidant in the body, the synthesis of cysteine, taurine, as well as other compounds necessary for optimal functioning, growth and regeneration, detoxification[11].
L-Histidine – previously considered non-essential for adults, histidine is involved in important mechanisms involving the immune, inflammatory and digestive systems. It is a precursor for a powerful antioxidant and for an effective UV light protector[12].
L-Tryptophan – helps release basic neurotransmitters, hormones for well-being and sleep. Examples include serotonin (the “hormone of happiness”) and melatonin (the hormone that regulates the sleep-wake cycle)[13].

“It is not protein that we need, it is amino acids:

essential, bio-available, orthomolecular (left-folded)”

100% essential amino acids; plant based. — Thot Aminos New Bottle – Golden

Read more about essential amino acids by accessing the main article:

Building blocks of life and nutrition – What are essential amino acids?

To find out more about the muscle – the organ of longevity – please read our article L-Leucine – the best key to muscle recovery, health and longevity in 2023,

2.3 L-Lysine – The Most Important Essential Amino Acid for Structural Integrity and BEAUTY

To begin with, L-Lysine, like all the other amino acids in Thot Aminos formula, is an essential amino acid, therefore it needs to be supplemented from an outside source: foods rich in L-Lysine or efficient supplements. The body cannot produce essential amino acids, but they are all vital for the body to accomplish its functions.

Thot Nutrition offers the best formula with the highest quality ingredients.

For biohacking style, we bring to you the best L-Lysine in the world – vegan, pure, orthomolecular, low molecule, high density, low molecule, top quality – ready for direct absorption and utilization.
Bralgei Shackry

Known for its beauty effects, L-Lysine is essential for collagen synthesis, but has multiple roles. The main ones are as it follows:

Functions and Benefits of L-Lysine:

It contributes to collagen synthesis and stabilization of the collagen matrix. Two of the key essential elements in collagen synthesis are L-lysine and vitamin C. One is an essential amino acid and the other is an essential vitamin. None can be produced by the body and need to be taken from outside.
Collagen is an essential structural protein that provides strength, elasticity and support to many tissues, including skin, tendons, ligaments and blood vessels. It’s what actually holds our cells together, in a structured and organized form! Without a solid collagen matrix we would be nothing more than a mass of cells of different shapes and sizes.
Participates in protein synthesis. L-lysine helps decode information stored in mRNA during the translation step, along with other amino acids. Apart from that, it is an essential amino acid that participates in the structure of proteins.
Supports muscle growth and recovery. Intense workouts put a lot of strain on the body, and an optimal collagen matrix ensures strong connective tissues, reducing the risk of injury. In addition, L-lysine facilitates the production of nitric oxide, known for vasodilation and oxygenation of muscles.
Improves liver function and lowers cholesterol levels. L-lysine is an essential amino acid involved in the production of digestive and metabolic enzymes that optimize triglyceride and cholesterol levels regulated by the liver.
Improves calcium absorption. L-Lysine improves calcium absorption from the intestines and potentiates the effects of vitamin D. By forming a strong collagen matrix in bones, calcium is retained in bone tissue in a greater proportion.
Strengthens the immune system. L-Lysine has significant antiviral activity, especially against simple herpesvirus HVS. It has immunomodulatory effects and stimulates the production of antibodies.
It can help manage herpes outbreaks. L-lysine has the ability to reduce the frequency, severity and duration of herpes outbreaks. The HSV virus requires the amino acid arginine to replicate. L-lysine and arginine compete for the absorption pathway, and it is thought that increasing lysine levels and reducing arginine levels may help suppress viral replication.[4]
Helps in the synthesis of hormones. L-lysine has the potential to stimulate the release of growth hormone from the pituitary gland. Growth hormone is essential for growth, development and maintenance of optimal body composition. L-lysine may also play a role in the synthesis of serotonin, known as the “hormone of happiness,” as well as other hormones, like all other essential amino acids.
Supports optimal brain activity. L-lysine is involved in the synthesis of various neurotransmitters, such as serotonin, dopamine and norepinephrine, involved in good mood and pleasure. Optimal levels of lysine contribute to dopamine production, supporting cognitive function, concentration, and motivation. It oxygenates the brain by stimulating nitric oxide synthesis and reducing inflammation and oxidative stress.
Maintains cardiovascular health. By engaging in collagen synthesis, L-lysine helps maintain strong , elastic and resilient blood vessels. In addition, it has the potential to reduce arterial plaque formation, known as atherosclerosis. Studies have also shown that L-lysine supplementation can help lower blood pressure levels.
Regulates gene expression.5]

These pathways all contribute to a healthy and beautiful body, especially the one involving collagen synthesis. We will now break down these mechanisms for you to better understand how exactly can L-Lysine significantly improve your body’s appearance in a way that is not only beautiful, but natural, healthy and long-lasting. Who wouldn’t want a truly long-lasting effect??

[1] Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002 Feb 8;277(6):4223-31.

[2] Byrdie – Lysine for Skin

[3] Building blocks of life and nutrition – What are essential amino acids?

[4] Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol. 1984 Dec;58(6):659-66.

[5] Dambacher S, Hahn M, Schotta G. Epigenetic regulation of development by histone lysine methylation. Heredity (Edinb). 2010 Jul;105(1):24-37.